Radioimmunoassay for Gastric Inhibitory Polypeptide
نویسندگان
چکیده
منابع مشابه
Gastric inhibitory polypeptide (GIP).
As long ago as 1930, Kosaka and Lim proposed a humoral agent capable of inhibiting gastric acid secretion after a meal. They coined the term enterogastrone. Using crude preparations of cholecystokinin-pancreozymin (CCK PZ) in dogs they were able to inhibit the acid secretion normally stimulated by a meat meal or histamine. They went on to experiment with duodenal extracts, prepared after the in...
متن کاملGastric inhibitory polypeptide links overnutrition to obesity.
Obesity and diabetes are two of the most prevalent health conditions in industrial nations. Recent studies suggest that a gut derived peptide, gastric inhibitory polypeptide (GIP), may be involved in the pathogenesis of type 2 diabetes and obesity induced by overnutrition. 2 The “thrifty genotype” hypothesis suggests that those who are prone to obesity have been favoured by natural selection in...
متن کاملGastric Inhibitory Polypeptide in the Brain
The hippocampus is an area of active cell proliferation and neurogenesis within the adult mammalian brain. Adult neurogenesis is of great importance for the brain, since it increases neuroplasticity and the ability to respond to environmental stimuli. It also provides a possible mechanism for the brain to replace lost cells that have died due to injury or disease. However, the molecular events ...
متن کاملGastric inhibitory polypeptide does not inhibit gastric emptying in humans.
The insulinotropic gut hormone gastric inhibitory polypeptide (GIP) has been demonstrated to inhibit gastric acid secretion and was proposed to possess "enterogastrone" activity. GIP effects on gastric emptying have not yet been studied. Fifteen healthy male volunteers (23.9 +/- 3.3 yr, body mass index 23.7 +/- 2.3 kg/m(2)) were studied with the intravenous infusion of GIP (2 pmol.kg(-1).min(-1...
متن کاملPancreatic and Extrapancreatic Effects of Gastric Inhibitory Polypeptide
The hormonal factor(s) implicated as transmitters of signals from the gut to pancreatic -cells is referred to as incretin, and gastric inhibitory polypeptide (GIP) is identified as one of the incretins. GIP is a gastrointestinal peptide hormone of 42 amino acids that is released from duodenal endocrine K-cells after absorption of glucose or fat and exerts its effects by binding to its specific ...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1974
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(74)80134-4